Buy 5-meo-dmt online

Buy 5-MeO-DMT Online

Buy 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and at least one toad species, the Sonoran Desert toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America.

Benefits and uses of 5-meo-dmt

5-MeO-DMT has been used as a healing agent by South American shamans for thousands of years, partially due to its ability to occasion mystical-type experiences. While research into the drug is still limited, recent studies are backing up these ancient claims.

In a survey of 362 adults, 80% of respondents reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. More than that, improvements were directly related to the intensity of the mystical effects felt during the experience. Respondents that had intense mystical experiences also reported higher rates of the experience’s personal meaning and spiritual significance.

The benefits of 5-MeO-DMT have also proven to be enduring—in a recent preliminary study, 42 participants who took 5-MeO-DMT reported an increase in levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks after the initial experience when a follow-up assessment was completed.

One of the unique aspects of 5-MeO-DMT is the short duration of the experience compared to more common psychedelics, such as LSD and psilocybin. While research has shown that psychedelic-assisted psychotherapy can help people with a variety of psychological disorders, these sessions often require a 7 to 8-hour session. Because 5-MeO-DMT is short-acting and lasts just 30-90 minutes, it shows promise as an accompaniment to therapy sessions, which are typically 60 to 90 minutes.

Effects of 5-meo-dmt

Pharmacology

Like the other tryptamines, 5-MeO-DMT has the same basic structure as DMT, but has a methoxy group in the R5 position. It works primarily through the serotonin (5-HT) system, with a particular binding affinity for the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter. Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function.

Toxicity

There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined. Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine. These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.

Some other safety concerns have been flagged by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary-grass) caused fatal tachycardia and respiratory failure. Although more likely due to other toxins in the plant, this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources.

Dosing

5-MeO-DMT doses are different depending on whether the substance is synthetic and naturally derived.

 

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